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23 Supplementation of 1 mg daily is recommended for patients with specific risk factors (e.g., bariatric/gastric surgery patients, those with severe malnutrition, chronic alcohol use, chronic hemolytic anemia and conditions with high cell turnover, and use of antimetabolite medications such as methotrexate)

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As with any emerging pharmacological agent, the establishment of a safe and effective dosage for clinical use necessitates thorough and rigorous clinical trials

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